ea0032p681 | Neuroendocrinology | ECE2013
Imbernon Monica
, Beiroa Daniel
, Vazquez Maria J
, Morgan Donald A
, Veyrat-Durebex Christelle
, Porteiro Begona
, Diaz-Arteaga Adenis
, Senra Ana
, Al-Massadi Omar
, Velasquez Douglas A
, Gallego Rosalia
, Seoane Luisa M
, Lopez Miguel
, Davis Roger J
, Sabio Guadalupe
, Rohner-Jeanrenaud Francoise
, Rahmouni Kamal
, Dieguez Carlos
, Nogueiras Ruben
Introduction: Melanin-concentrating hormone (MCH) is an orexigenic neuropeptide which is located in the lateral hypothalamus and regulate the energy balance. MCH deficient mice are hypophagic, lean and do not develop hepatosteatosis when fed on high fat diet. The MCH increases food intake and adiposity, so we sought to investigate the role of the MCH on adipocyte and hepatic metabolism.Methods: MCH were chronically administered into the lateral ventricle...